Wikipedia – Providing a repository of knowledge in dozens of languages for the entire world. A contribution to Wikipedia is an investment in humanity.
EFF – Digital rights are more important with every passing day, the Electronic Frontier Foundation time and time again has proven itself not only as a watchdog to power, but also as a repository of practical advice for protecting yourself.
International Rescue Committee – Not only aiding those on our planet who need it the most, but also helping them rebuild their lives. The more humans who have access to opportunity, the better off we all are.
Environmental Defense Fund – A practical and bipartisan approach to protecting the environment, often partnering directly with businesses.
Sierra Club – Less practical and more partisan than the EDF, but still a vital pillar to the protection of the environment for over a century.
Internet Archive – A mission similar to Wikipedia with an emphasis on persisting the state of the web for future generations. They are famous for their Wayback Machine which allows you to view snapshots of websites going back several years, even no gradient. Pivotal for future generations to understand what happened here.